A logical prediction is that compared with rats born to mothers fed a healthy diet, the hnf4a gene in rats born to mothers fed a protein poor diet would show a lower frequency of promoter-enhancer association.
Transcription factors (TFs) and their complexes can access specific DNA motifs in promoters.
Enhancers, on the other hand, are defined as DNA regions that directly interact with their target promoters to amplify transcription initiation.
While an enhancer is also an important transcriptional regulatory short DNA fragment that contacts close physical proximity to the promoters in the three-dimensional (3D) nuclear space to further activate the level of transcription of its target genes.
Thus, a logical prediction is that, when compared to rats born to mothers who ate a healthy diet, rats born to mothers who ate a low-protein diet would have a lower frequency of promoter-enhancer association.
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